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Article Publish Status: FREE
Abstract Title:

Lipid Modulating Anti-oxidant Stress Activity of Gastrodin on Nonalcoholic Fatty Liver Disease Larval Zebrafish Model.

Abstract Source:

Int J Mol Sci. 2019 Apr 23 ;20(8). Epub 2019 Apr 23. PMID: 31018538

Abstract Author(s):

Owais Ahmad, Bing Wang, Kejian Ma, Yang Deng, Maoru Li, Liping Yang, Yuqi Yang, Jingyun Zhao, Lijun Cheng, Qinyang Zhou, Jing Shang

Article Affiliation:

Owais Ahmad

Abstract:

Non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the world. However, there are still no drugs for NAFLD/NASH in the market. Gastrodin (GAS) is a bioactive compound that is extracted fromwhich is used as an active compound on nervous system diseases. Recent reports showed that GAS andpossess anti-oxidant activity and lipid regulating effects, which makes us curious to reveal the anti-NAFLD effect of GAS. A high cholesterol diet (HCD) was used to induce a NAFLD larval zebrafish model, and the lipid regulation and anti-oxidant effects were tested on the model. Furthermore, qRT-PCR studied the underlying mechanism of GAS. To conclude, this study revealed a lipid regulation and anti-oxidant insights of GAS on NAFLD larval zebrafish model and provided a potential therapeutic compound for NAFLD treatment.

Study Type : Animal Study

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Sayer Ji
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