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Abstract Title:

Effect of thimerosal on the neurodevelopment of premature rats.

Abstract Source:

World J Pediatr. 2013 Nov ;9(4):356-60. Epub 2013 Nov 14. PMID: 24235069

Abstract Author(s):

Yan-Ni Chen, Jue Wang, Jie Zhang, Su-Jiao Li, Li He, Dong-Dong Shao, Hui-Ying Du

Article Affiliation:

Yan-Ni Chen

Abstract:

BACKGROUND: This study was undertaken to determine the effect of thimerosal on the neurodevelopment of premature rats.

METHODS: Thimerosal was injected into premature SD rats at a dose of 32.8, 65.6, 98.4 or 131.2μg/kg on postnatal day 1. Expression of dopamine D4 receptor (DRD4) and serotonin 2A receptor (5-HT2AR), apoptosis in the prefrontal cortex on post-injection day 49, and learning and memory function were studied and compared with those in a control group injected with saline.

RESULTS: Expression of DRD4 and 5-HT2AR and learning function decreased, and apoptosis increased significantly in the 131.2μg/kg group (P<0.001). Memory function was significantly impaired by 65.6 (P<0.05), 98.4 and 131.2μg/kg (P<0.001).

CONCLUSIONS: The negative adverse consequences on neurodevelopment observed in the present study are consistent with previous studies; this study raised serious concerns about adverse neurodevelopmental disorder such as autism in humans following the ongoing worldwide routine administration of thimerosalcontaining vaccines to infants.

Study Type : Animal Study

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