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Abstract Title:

Organochlorine Levels in Plasma and Risk of Multiple Myeloma.

Abstract Source:

J Occup Environ Med. 2018 Oct ;60(10):911-916. PMID: 30289833

Abstract Author(s):

Leah Weber, Kevin Song, Terry Boyle, Éric Gaudreau, Agnes Lai, Heather J Sutherland, Alain LeBlanc, John J Spinelli

Article Affiliation:

Leah Weber

Abstract:

OBJECTIVE: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM).

METHODS: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls.

RESULTS: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio = 7.44; 95% confidence interval = 4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and β-hexachlorocyclohexane (β-HCCH) were identified as significant independent predictors of MM.

CONCLUSION: Our study provides evidence that organochlorines contribute to the risk of MM.

Study Type : Human Study

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Sayer Ji
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