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Article Publish Status: FREE
Abstract Title:

MiR-23a targets RUNX2 and suppresses ginsenoside Rg1-induced angiogenesis in endothelial cells.

Abstract Source:

Oncotarget. 2017 Aug 29 ;8(35):58072-58085. Epub 2017 Jul 22. PMID: 28938538

Abstract Author(s):

Xiao-Dong Wu, Ting Guo, Li Liu, Chao Wang, Kun Zhang, Han-Qiang Liu, Feng Wang, Wen-Dong Bai, Meng-Yao Zhang

Article Affiliation:

Xiao-Dong Wu

Abstract:

Rg1 is a predominant protopanaxatriol-type of ginsenoside found in Panax ginseng, and it has been shown to have anti-cancer effects in multiple types of cancer cells. However, Rg1 also induces the expression of proangiogenic factors, such as vascular endothelial growth factor (VEGF-A), in endothelial cells. Unfortunately, angiogenesis positively correlates with cancer development. In this study, we identified RUNX2 as a regulator of ginsenoside Rg1-induced angiogenesis for the first time. We found that RUNX2 was directly targeted and regulated by miR-23a. Additionally, miR-23a was shown to inhibit angiogenesis in both human umbilical vein endothelial cells (HUVECs) and in zebrafish. Furthermore, a decrease in RUNX2 expression resulted in translational repression of VEGF-A in HUVECs. Taken together, this study identified a MiR-23a/RUNX2/VEGF-A pathway in angiogenesis and shed light on the molecular mechanism of Rg1-induced angiogenesis. Thus, RUNX2 might be a potential therapeutic target in Rg1-mediated angiogenesis in cancer.

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Sayer Ji
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