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Article Publish Status: FREE
Abstract Title:

Study on optimisation of extraction process of tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cell apoptosis.

Abstract Source:

Afr J Tradit Complement Altern Med. 2013 ;10(6):456-8. Epub 2013 Oct 3. PMID: 24311868

Abstract Author(s):

Jianhong Hou, Jiantai He, Xin Jin, Tian Hu, Yangde Zhang

Article Affiliation:

Jianhong Hou

Abstract:

The objective of this paper was to investigate the extraction process of tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cell apoptosis. Extraction process of tanshinone IIA was optimised by orthogonal experimental method, and its effect on gastric cancer SGC7901 cell apoptosis was observed using MTT assay and electron microscopy. The optimum extraction process of tanshinone IIA was as follows: addition of a 10-fold amount of 80% ethanol, one-time extraction, and extraction time of 45 minutes. The study concluded that tanshinone IIA can induce apoptosis of gastric cancer SGC7901 cells.

Study Type : In Vitro Study

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Sayer Ji
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