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Abstract Title:

Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis.

Abstract Source:

World J Gastroenterol. 2010 Apr 7;16(13):1622-30. PMID: 20355240

Abstract Author(s):

Cecilia Rodríguez, Marta Medici, Fernanda Mozzi, Graciela Font de Valdez

Article Affiliation:

Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, San Miguel de Tucumán, 4000, Tucumán, Argentina.

Abstract:

AIM: To investigate the potential therapeutic effect of exopolysaccharide (EPS)-producing Streptococcus thermophilus (S. thermophilus) CRL 1190 fermented milk on chronic gastritis in Balb/c mice. METHODS: Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 mg/kg body weight per day for 10 d). Omeprazole was included in this study as a positive therapeutic control. The gastric inflammatory activity was evaluated from gastric histology and inflammation score, number of interleukin-10 (IL-10), interferon-gamma (INFgamma) and tumor necrosis factor-alpha (TNF-alpha) cytokine-producing cells in the gastric mucosa, and thickness of the mucus layer. RESULTS: Animals receiving treatment with the EPS-producing S. thermophilus CRL 1190 fermented milk showed a conserved gastric mucosa structure similar to that of healthy animals. Inflammation scores of the fermented milk-treated mice were lower than those of mice in the gastritis group (0.2 + or - 0.03 vs 2.0 + or - 0.6, P<0.05). A marked decrease in INFgamma(+) (15 + or - 1.0 vs 28 + or - 1.2, P<0.05) and TNF-alpha(+) (16 + or - 3.0 vs 33 + or - 3.0, P<0.05) cells and an increase in IL-10(+) (28 + or - 1.5 vs 14 + or - 1.3, P<0.05) cells compared to the gastritis group, was observed. Also, an increase in the thickness of the mucus gel layer (2.2 + or - 0.6 vs 1.0 + or - 0.3; 5.1 + or - 0.8 vs 1.5 + or - 0.4 in the corpus and antrum mucosa, respectively, P<0.05) compared with the gastritis group was noted. A milk suspension of the purified EPS from S. thermophilus CRL1190 was also effective as therapy for gastritis. CONCLUSION: This study suggests that fermented milk with S. thermophilus CRL 1190 and/or its EPS could be used in novel functional foods as an alternative natural therapy for chronic gastritis induced by ASA.

Study Type : Animal Study

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