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Article Publish Status: FREE
Abstract Title:

Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage.

Abstract Source:

Nutrients. 2017 Jun 14 ;9(6). Epub 2017 Jun 14. PMID: 28613256

Abstract Author(s):

Massimiliano Gasparrini, Tamara Y Forbes-Hernandez, Sadia Afrin, Patricia Reboredo-Rodriguez, Danila Cianciosi, Bruno Mezzetti, Josè L Quiles, Stefano Bompadre, Maurizio Battino, Francesca Giampieri

Article Affiliation:

Massimiliano Gasparrini

Abstract:

Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50μg/mL)-based formulations supplemented with Coenzyme Q10 (100 μg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidantand inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p<0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents.

Study Type : Human In Vitro

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Sayer Ji
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