Effects of Stilbene Components of Roots of Polygonum ssp. on Liver Injury in Peroxidized Oil-fed Rats.
Planta Med. 1983 Sep;49(9):51-4. PMID: 17405012
2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Ehime, Japan.
The effects of POLYGONUM CUSPIDATUM S IEB. et Z UCC. ("Kojo-kon" or "Itadori-kon" in Japanese) of POLYGONUM MULTIFLORUM ("Kashuwu" or "Tsurudo-kudami-kon" in Japanese) roots and their stilbene components (piceid and 2,3,5,4'-tetrahydroxy stilbene-2-O-D-glucoside) on liver injury caused in rats by feeding peroxidized oil were investigated. Piceid and 2,3,5,4'-tetrahydroxy stilbene-2-O-D-glucoside were found to partly inhibit the deposition of lipid peroxides in the liver of those rats. The stilbene glucosides reduced the elevation of GOT and GPT levels in the serum of the rats. Furthermore, resveratrol, piceid and 2,3,5,4'-tetrahydroxy stilbene-2-O-D-glucoside were found to inhibit lipid peroxidation induced by ADP and NADPH in rat liver microsomes.