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Abstract Title:

St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling.

Abstract Source:

Cancer Prev Res (Phila). 2015 Sep ;8(9):786-95. Epub 2015 Jun 11. PMID: 26069204

Abstract Author(s):

Soumen K Manna, Srujana Golla, Jaya Prakash Golla, Naoki Tanaka, Yan Cai, Shogo Takahashi, Kristopher W Krausz, Tsutomu Matsubara, Ilia Korboukh, Frank J Gonzalez

Article Affiliation:

Soumen K Manna

Abstract:

Despite widespread use as well as epidemiologic indications, there have been no investigations into the effect of St. John's wort (SJW) extract on colorectal carcinogenesis in vivo. This study reports a systematic evaluation of the impact of dietary supplementation of SJW extract on azoxymethane-induced colorectal carcinogenesis in mice. Mice were fed with either AIN-93G (control) diet or SJW extract-supplemented diet (SJW diet) prior to azoxymethane treatment. SJW diet was found to significantly improve the overall survival of azoxymethane-treated mice. Pretreatment with the SJW diet significantly reduced body weight loss as well as decrease of serum albumin and cholesterol levels associated with azoxymethane-induced colorectal tumorigenesis. SJW diet-fed mice showed a significant decrease in tumor multiplicity along with a decrease in incidence of large tumors and a trend toward decreased total tumor volume in a dose-dependent manner. A short-term study, which examined the effect of SJW prior to rectal bleeding, also showed decrease in colorectal polyps in SJW diet-fed mice. Nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinase (ERK1/2) pathways were attenuated by SJW administration. SJW extract resulted in early and continuous attenuation of these pathways in the colon epithelium of SJW diet-fed mice under both short-term and long-term treatment regimens. In conclusion, thisstudy demonstrated the chemopreventive potential of SJW extract against colorectal cancer through attenuation of proinflammatory processes. Cancer Prev Res; 8(9); 786-95. ©2015 AACR.

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Sayer Ji
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