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Abstract Title:

The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo-controlled double-blind clinical trial.

Abstract Source:

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Sep;154(3):239-44. PMID: 21048810

Abstract Author(s):

Ales Vidlar, Jitka Vostalova, Jitka Ulrichova, Vladimir Student, Milan Krajicek, Jana Vrbkova, Vilim Simanek

Article Affiliation:

Department of Urology, University Hospital, Olomouc, Czech Republic.

Abstract:

BACKGROUND: Silymarin, a milk thistle flavonolignan mixture, has anti-proliferative and anti-angiogenic activities in xenografts of human prostate cancer (PCa). Low dietary selenium on the other hand has been associated with increased incidence of PCa. The purpose of the current trial was to determine whether a daily administration of a silymarin and selenium (SM-Se) combination for 6 months would alter basic clinical chemistry and oxidative stress markers, and improve the quality of life score (QoL) in men after radical prostatectomy (RP). METHODS: Thirty seven participants, 2-3 months after RP, were randomly assigned to receive 570 mg of silymarin and 240µg of selenium as selenomethionine (n = 19, SM-Se group) or placebo (n = 18, Placebo group) daily for six months. Both groups had similar clinical and demographic characteristics. Physical examination, QoL score, haematology, basic clinical chemistry and oxidative stress markers, selenium and testosterone levels, antioxidant status were evaluated at baseline, at 3 and 6 months. RESULTS: The six months administration of silymarin and selenium improved the QoL score, decreased low density lipoproteins (LDL) and total cholesterol and, increased serum selenium levels. The combination had no effect on blood antioxidant status and no influence on testosterone level. No adverse events were recorded. No improvement was found in the placebo group. CONCLUSIONS: The selected combination of silymarin and selenium significantly reduced two markers of lipid metabolism known to be associated with PCaprogression, LDL and total cholesterol in the blood of men after RP. This suggests that this combination may be effective in reducing PCa progression.

Study Type : Human Study

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Sayer Ji
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