Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Short-term effects of l-citrulline supplementation on arterial stiffness in middle-aged men.

Abstract Source:

Int J Cardiol. 2010 Nov 8. Epub 2010 Nov 8. PMID: 21067832

Abstract Author(s):

Masayuki Ochiai, Toshio Hayashi, Masahiko Morita, Koichiro Ina, Morihiko Maeda, Fumiko Watanabe, Koji Morishita

Article Affiliation:

Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD., 2, Miyukigaoka, Tsukuba-shi, Ibaraki 305-0841, Japan.

Abstract:

BACKGROUND: Nitric oxide (NO) plays a key role in the maintenance of vascular tone, contributing to the functional regulation of arterial stiffness. Although oral l-citrulline could become the effective precursor of l-arginine (substrate for endothelial NO synthase) via the l-citrulline/ l-arginine pathway, little is known about the efficacy of l-citrulline application on arterial stiffness. OBJECTIVE: We examined the short-term effects of l-citrulline supplementation on arterial stiffness in humans. METHODS: In a double-blind, randomized, placebo-controlled parallel-group trial, 15 healthy male subjects (age: 58.3±4.4years) with brachial-ankle pulse wave velocity (baPWV; index of arterial stiffness>1400cm/sec) were given 5.6g/day of l-citrulline (n=8) or placebo (n=7) for 7days. baPWV and various clinical parameters were measured before (baseline) and after oral supplementation of l-citrulline or placebo. RESULTS: Compared with the placebo group, baPWV was significantly reduced in the l-citrulline group (p<0.01). No significant differences in blood pressure (BP) were found between the two groups, and no correlation was observed between BP and baPWV. The serum nitrogen oxide (NOx, the sum of nitrite plus nitrate) and NO metabolic products were significantly increased only in the l-citrulline group (p<0.05). Plasma citrulline, arginine and the ratio of arginine/asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase (arginine/ADMA ratio) were significantly increased in the l-citrulline group compared with the placebo group (p<0.05, p<0.01, p<0.05, respectively). Moreover, there was a correlation between the increase of plasma arginine and the reduction of baPWV (r=-0.553, p<0.05). CONCLUSION: These findings suggest that short-term l-citrulline supplementation may functionally improve arterial stiffness, independent of blood pressure, in humans.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.