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Abstract Title:

Severe rhabdomyolysis due to rosuvastatin in a liver transplant subject with human immunodeficiency virus and immunosuppressive therapy-related dyslipidemia.

Abstract Source:

Liver Transpl. 2011 Mar;17(3):331-3. PMID: 21384516

Abstract Author(s):

Ana Moreno, Jesús Fortún, Javier Graus, Miguel A Rodriguez-Gandía, Carmen Quereda, María J Pérez-Elías, Javier Nuño, Philip Wikman, Santiago Moreno, Rafael Bárcena

Article Affiliation:

Infectious Diseases Service, Hospital Ramón y Cajal, Madrid, Spain. amoreno.hrc@salud.madrid.org.

Abstract:

Statins are relatively safe first-line agents to use in the setting of dyslipidemia associated with immunosuppressive therapy in subjects undergoing liver transplantation, and also in HIV-infected patients with dyslipidemia due to antiretroviral drugs, especially ritonavir-boosted protease inhibitors. Rosuvastatin, a new statin, has demonstrated higher potency than previously released statins and is not extensively metabolized by the liver P450 system; therefore, the probability of deleterious pharmacokinetic interactions with commonly used immunosuppressants and antiretroviral drugs is reduced. We present the first case of severe rhabdomyolysis in a liver transplant patient receiving rosuvastatin for the treatment of immunosuppressive therapy-related grade IV dyslipidemia, an HIV-infected subject on protease inhibitor-sparing HAART, that resolved after rosuvastatin withdrawal, probably related to interactions between calcineurin inhibitors and hepatic rosuvastatin uptake transporters such as Organic Anion Transporting Polypeptides (OATPs). Liver Transpl, 2011.© 2011 AASLD.

Study Type : Human: Case Report
Additional Links
Problem Substances : Rosuvastatin : CK(71) : AC(17)
Adverse Pharmacological Actions : Myotoxicity : CK(327) : AC(80)

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