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Article Publish Status: FREE
Abstract Title:

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction.

Abstract Source:

Mol Med Rep. 2017 May ;15(5):2949-2956. Epub 2017 Mar 30. PMID: 28358428

Abstract Author(s):

Tran Duong Thuy, Nam Nhut Phan, Chih-Yang Wang, Han-Gang Yu, Shu-Yin Wang, Pung-Ling Huang, Yi-Yin Do, Yen-Chang Lin

Article Affiliation:

Tran Duong Thuy

Abstract:

Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes>40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.

Study Type : Animal Study

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Sayer Ji
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