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Abstract Title:

Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K/AKT/GSK-3β/NRF-2 signalling pathway.

Abstract Source:

Arch Physiol Biochem. 2017 Sep 14:1-9. Epub 2017 Sep 14. PMID: 28906145

Abstract Author(s):

Noura M Thabet, Enas M Moustafa

Article Affiliation:

Noura M Thabet

Abstract:

This study was designed to evaluate the effect of rutin on PI3K/AKT-signalling in case of acrylamide orγ-radiation-induced neurotoxicity. To induce brain damage, animals were received acrylamide (25 mg/kg b.wt./orally/day) or 5 Gy of γ-radiation exposure accompanied with an administration of rutin (200 mg/kg b.wt./orally/day). Our data revealed that, compared to acrylamide or γ-radiation, rutin activated PI3K/AKT/GSK-3β/NRF-2-pathway through increased protein levels of p-PI3K, p-AKT and p-GSK-3β and up-regulated the expression of NRF-2. This was achieved by modulating MDA, GST, IL-1β, IL-6 and reduced the interference of ROS with IGF-1 and NGF stimulating the PI3K/AKT-signaling. Furthermore, histopathological examinations of brain tissues showed that rutin has modulated tissue architecture after acrylamide or γ-radiation induced tissue damage. It could be concluded that rutin provides protection effect against acrylamide or γ-radiation-induced neurotoxicity via activation ofthe PI3K/AKT/GSK-3β/NRF-2-pathway by altering the phosphorylation state through its ability to scavenge free radicals generation, modulating gene expression and its anti-inflammatory effects.

Study Type : Animal Study

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Sayer Ji
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