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Abstract Title:

Hypolipidemic and Hypocholesterolemic Effect of Roselle (Hibiscus sabdariffa L.) Seeds Oil in Experimental Male Rats.

Abstract Source:

J Oleo Sci. 2017 ;66(1):41-49. PMID: 28049927

Abstract Author(s):

Rehab F M Ali, Ayman M El-Anany

Article Affiliation:

Rehab F M Ali

Abstract:

The current investigation aimed to evaluate the influence of roselle seeds oil (RSO), coconut oil (CNO) and binary mixture of them on serum lipids of experimental rats. Fatty acid composition of native and blended oils was determined. Thirty five male Albino rats (145- 160 g) were used throughout this study. The rats were fed AIN-93G diet containing 10% fat from CNO, RSO, B1 (25%RSO+ 75 %CNO), B2 (50 %RSO+ 50 %CNO or B3 (75 %RSO+ 25 % CNO) for eight weeks. Blood samples were collected at the beginning, every two weeks during the experiment, and at the end of the experiment. At the time of sacrifice, organs weights in relation to their body weights were immediately recorded. Substitution of 25, 50 and 75 % of CNO with equal amounts of RSO reduced saturated fatty acids by 16.04, 32.58 and 48.77 %, respectively in blended oils. The content of linoleic (C18:2) increased from not detected level in CNO to 9.81, 19.67 and 29.48 % in CNO blended with 25, 50 and 75 % of RSO, respectively. The relative liver weights of rats fed CNO was significantly higher than that of those fed RSO and blended oils. Mixing CNO with various levels of RSO attenuates the adverse effect in the relative liver weights which caused by CNO administration. At the end of the experiment, blinding coconut oil with 25, 50 and 75 % of roselle oil inhibited the elevation in total cholesterol by 9.69, 28.16 and 36.16 %, respectively compared to CNO rats. Rats fed diet containing CNO for 8 weeks had significantly the highest content (126.49 mg/dl) of low-density lipoprotein cholesterol, while those fed 100 % RSO (as a source of lipids) had the lowest concentration of LDL-C (64.32 mg/dL). Atherogenic index (AI) values of rats submitted B1, B2 and B3 were about 1.12, 1.23 and 1.28 times as low as those of rats fed CNO diet, respectively. The results of this study indicate that roselle seeds oil (RSO) reduces hyperlipidemia and hypercholesterolemia in rats fed diet rich in saturated fatty acids.

Study Type : Animal Study

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