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Abstract Title:

Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.

Abstract Source:

Food Chem. 2013 Dec 1 ;141(3):2108-16. Epub 2013 May 16. PMID: 23870935

Abstract Author(s):

Shuai Zhang, Lingli Zheng, Deshi Dong, Lina Xu, Lianhong Yin, Yan Qi, Xu Han, Yuan Lin, Kexin Liu, Jinyong Peng

Article Affiliation:

Shuai Zhang

Abstract:

The effects and mechanisms of the total flavonoids (TFs) from Rosa laevigata Michx fruit on high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) were investigated in this study. Gavage administration of the TFs significantly decreased the relative liver weight, serum AST and ALT activities, the levels of serum lipid, LDL, blood glucose and insulin, suppressed lipid accumulation in liver, and increased serum HDL level. Moreover, the natural product significantly enhanced SOD activity, increased GSH-Px and GSH contents and decreased the concentration of MDA and CYP2E1 expression as well as prevented mitochondrial membrane potential dysfunctions and ultrastructural alterations. Further mechanism investigation indicated that the TFs inhibited hepatic lipid accumulation by suppressing the expressions of some key molecules in fatty acid synthesis pathway and promoting fatty acidβ-oxidation, while not by inhibiting cholesterol synthesis. On the base of these, the TFs should be developed as a new drug for treatment of NAFLD.

Study Type : Animal Study

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Sayer Ji
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