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Article Publish Status: FREE
Abstract Title:

The Therapeutic Potential of Naringenin: A Review of Clinical Trials.

Abstract Source:

Pharmaceuticals (Basel). 2019 Jan 10 ;12(1). Epub 2019 Jan 10. PMID: 30634637

Abstract Author(s):

Bahare Salehi, Patrick Valere Tsouh Fokou, Mehdi Sharifi-Rad, Paolo Zucca, Raffaele Pezzani, Natália Martins, Javad Sharifi-Rad

Article Affiliation:

Bahare Salehi

Abstract:

Naringenin is a flavonoid belonging to flavanones subclass. It is widely distributed in severalfruits, bergamot, tomatoes and other fruits, being also found in its glycosides form (mainly naringin). Several biological activities have been ascribed to this phytochemical, among them antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic and cardioprotective effects. Nonetheless, most of the data reported have been obtained fromorstudies. Although some clinical studies have also been performed, the main focus is on naringenin bioavailability and cardioprotective action. In addition, these studies were done in compromised patients (i.e., hypercholesterolemic and overweight), with a dosage ranging between 600 and 800μM/day, whereas the effect on healthy volunteers is still debatable. In fact, naringenin ability to improve endothelial function has been well-established. Indeed, the currently available data are very promising, but further research on pharmacokinetic and pharmacodynamic aspects is encouraged to improve both available production and delivery methods and to achieve feasible naringenin-based clinical formulations.

Study Type : Review

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Sayer Ji
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