Therapeutic Potential and Cellular Mechanisms of Panax Notoginseng on Prevention of Aging and Cell Senescence-Associated Diseases.
Aging Dis. 2017 Dec ;8(6):721-739. Epub 2017 Dec 1. PMID: 29344413
Owing to a dramatic increase in average life expectancy, most countries in the world are rapidly entering an aging society. Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the spotlight of gerosciences.(Burk.) F. H. Chen, a species of the genus Panax, has been called the"Miracle Root for the Preservation of Life,"and has long been used as a Chinese herb with magical medicinal value.has been extensively employed in China to treat microcirculatory disturbances, inflammation, trauma, internal and external bleeding due to injury, and as a tonic. In recent years, with the deepening of the research pharmacologically, many new functions have been discovered. This review will introduce its pharmacological function on lifespan extension, anti-vascular aging, anti-brain aging, and anti-cancer properties, aiming to lay the ground for fully elucidating the potential mechanisms ofanti-aging effect to promote its clinical application.