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Article Publish Status: FREE
Abstract Title:

The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review.

Abstract Source:

Saudi J Kidney Dis Transpl. 2009 Sep ;20(5):741-52. PMID: 19736468

Abstract Author(s):

Ahmed Ragheb, Ahmed Attia, Walid Shehab Eldin, Fawzy Elbarbry, Sana Gazarin, Ahmed Shoker

Article Affiliation:

Ahmed Ragheb

Abstract:

Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including anti-oxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulonephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demonstrated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans.

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Sayer Ji
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