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Article Publish Status: FREE
Abstract Title:

The current state and future perspectives of cannabinoids in cancer biology.

Abstract Source:

Cancer Med. 2018 Mar ;7(3):765-775. Epub 2018 Feb 23. PMID: 29473338

Abstract Author(s):

Paweł Śledziński, Joanna Zeyland, Ryszard Słomski, Agnieszka Nowak

Article Affiliation:

Paweł Śledziński

Abstract:

To date, cannabinoids have been allowed in the palliative medicine due to their analgesic and antiemetic effects, but increasing number of preclinical studies indicates their anticancer properties. Cannabinoids exhibit their action by a modulation of the signaling pathways crucial in the control of cell proliferation and survival. Many in vitro and in vivo experiments have shown that cannabinoids inhibit proliferation of cancer cells, stimulate autophagy and apoptosis, and have also a potential to inhibit angiogenesis and metastasis. In this review, we present an actual state of knowledge regarding molecular mechanisms of cannabinoids' anticancer action, but we discuss also aspects that are still not fully understood such as the role of the endocannabinoid system in a carcinogenesis, the impact of cannabinoids on the immune system in the context of cancer development, or the cases of a stimulation of cancer cells' proliferation by cannabinoids. The review includes also a summary of currently ongoing clinical trials evaluating the safety and efficacy of cannabinoids as anticancer agents.

Study Type : Review

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Sayer Ji
Founder of GreenMedInfo.com

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