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Abstract Title:

[Research on resveratrol's effects on suppressing growth and inducing apoptosis of GBC cells].

Abstract Source:

Zhong Yao Cai. 2005 Jun;28(6):489-91. PMID: 16209266

Abstract Author(s):

Li Sheng, Lifeng An, Ye He, Guixiang Fan, Yukang Yuan

Article Affiliation:

Department of Immunology, Medical College, Xi'an Jiaotong University, Xi'an.

Abstract:

OBJECTIVE: To explore the contribution of resveratrol (Res) to the proliferation and apoptosis of gallbladder carcinoma (GBC) cell line as well as fibroblast 3T3 cell line in vitro. METHODS: The tumor cell growth repressing rate was measured by the MTT method,and flow cytometry was used to analyse cell cycle. The gene expression of bcl-2 c-myc p53 were examined by SABC. RESULTS: Res obviously suppressed the proliferation (P<0. 01) in concentration and time dependent manner, it's tiptop was 54%. Res could induce apoptosis of tumor cells. The maximum apoptosis rate of tumor was 30. 52%, experiment group compared with comparison group Gl's cells rised from 34. 88% to 55.47 +/- 3. 95%, S's cells reduced 8.41 - 17.54%, which showed obvious phenomenon of G0/G1 blocking. The GBC cell's bcl-2, c-myc gene reduced expression,while p53 gene increased expression. CONCLUSION: The results of this study confirm the ability of Res to suppress the proliferation of gallbladder carcinoma (GBC) cell with a typical apoptotic feature in vitro. Therefore, Res may be considered as a possible treatment strategy for gallbladder carcinoma.

Study Type : In Vitro Study

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Sayer Ji
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