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Abstract Title:

Resveratrol inhibits hepatocellular carcinoma progression driven by hepatic stellate cells by targeting Gli-1.

Abstract Source:

Mol Cell Biochem. 2017 Apr 28. Epub 2017 Apr 28. PMID: 28455791

Abstract Author(s):

Yu Yan, Cancan Zhou, Jie Li, Ke Chen, Guanghui Wang, Guangbing Wei, Mingwei Chen, Xuqi Li

Article Affiliation:

Yu Yan

Abstract:

Hepatocellular carcinoma (HCC) is characterized by hypervascularity. Hepatic stellate cells (HSCs) play very important roles in HCC malignant progression, as these cells facilitate HCC tumorigenesis and metastasis. We demonstrated that HSCs induce angiogenesis in HCC by upregulating the expression of Gli-1, which stimulates reactive oxygen species (ROS) production and potentiates increases in HCC cell invasiveness. Resveratrol abolished HSC-induced angiogenesis and suppressed ROS production and IL-6 and CXCR4 receptor expression in HepG2 cells by down-regulating Gli-1 expression. These findings indicate that Gli-1 may be a target for the prevention of angiogenesis in HCC and that resveratrol may have beneficial effects with respect to preventing HCC progression.

Study Type : In Vitro Study

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