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Article Publish Status: FREE
Abstract Title:

Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma.

Abstract Source:

Evid Based Complement Alternat Med. 2016 ;2016:6087213. Epub 2016 May 17. PMID: 27293462

Abstract Author(s):

Yoshiki Mukudai, Meilin Zhang, Sunao Shiogama, Seiji Kondo, Chihiro Ito, Hiromi Motohashi, Kosuke Kato, Miharu Fujii, Satoru Shintani, Hideyuki Shigemori, Kazunaga Yazawa, Tatsuo Shirota

Article Affiliation:

Yoshiki Mukudai

Abstract:

Squamous cell carcinoma (SCC) is one of the most common cancers of the head and neck region worldwide and is generally treated surgically in combination with radiotherapy and/or chemotherapy. However, anticancer agents have numerous serious side effects, and alternative, less toxic agents that are effective as chemotherapeutics for SCC are required. The Paeoniaceae family is widely used in traditional Chinese medicine. We examined methanol and butanol extracts of Paeonia lutea (P. lutea) leaves for their potential as an anticancer agent. Both extracts decreased the proliferation of SCC cells, induced apoptotic cell death, and modulated migration, adhesion, chemotaxis, and haptotaxis in an extracellular matrix- (ECM-) dependent manner due to altered expression of several integrin subunits. Subsequently, SCC cells were subcutaneously transplanted into athymic nude mice; the extracts reduced the metastasis of SCC cells but had little effect on the volume of the primary tumor or survival or body weight of the mice. The results suggest that the extracts may hold promise for preventing cancer metastasis.

Study Type : In Vitro Study

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Sayer Ji
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