Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Reseda luteola L. extract displays antiproliferative and pro-apoptotic activities that are related to its major flavonoids.

Abstract Source:

Environ Health Prev Med. 2010 Jan;15(1):18-26. PMID: 19960424

Abstract Author(s):

U Woelfle, B Simon-Haarhaus, I Merfort, C M Schempp

Article Affiliation:

Competence Center skintegral, Department of Dermatology, University Medical Center Freiburg, Hauptstr. 7, D-79104 Freiburg, Germany.

Abstract:

Reseda luteola L. has been used as a dye due to its high luteolin content since ancient times. However, no pharmacological studies have been performed with Reseda extracts so far. Here, we have assessed antiproliferative and apoptosis-inducing effects of the Reseda extract RF-40. It contains 40% flavonoids, primarily luteolin, but also luteolin-7-O-glucoside and apigenin. RF-40 and the isolated flavonoids dose-dependently inhibited cell proliferation and induced apoptotic oligonucleosomes in PHA-stimulated peripheral blood mononuclar cells. These effects were not due to cytotoxicity as shown with a luminometric ATP assay. Dose-response curves of RF-40 and the isolated flavonoids were similar, with luteolin being the most effective isolated flavonoid. Comparison of RF-40 to its major flavonoids revealed that the pharmacological effects of the extract can mostly be attributed to luteolin. We conclude that Reseda extract is an interesting raw material not only for dyeing purposes but also for further pharmacological investigation. Copyright (c) 2009 John Wiley&Sons, Ltd.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.