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Article Publish Status: FREE
Abstract Title:

Regular Exercise Training with Lutein/zeaxanthin Isomers Regulates Brain Transcription Factors and Neurotrophic and Synaptic Proteins in Rats (P06-020-19).

Abstract Source:

Curr Dev Nutr. 2019 Jun ;3(Suppl 1). Epub 2019 Jun 13. PMID: 31223768

Abstract Author(s):

Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Vijaya Juturu

Article Affiliation:

Kazim Sahin

Abstract:

Objectives: Lutein/zeaxanthin isomers (L/Zi), the major carotenoids, have demonstrated potent antioxidant and antiinflammation. This study was conducted to clarify the effects of L/Zi on brain transcription and brain-derived neurotrophic factors and synaptic proteins combined with exercise training in rats.

Methods: Wistar rats (age: 8 wks) were allocated into four groups: (i) Control: no treatments (ii) L/Zi: Rats treated with L/Zi (100 mg L/Zi/kg BW); (iii) Exercise: Rats with regular exercise only, (iv) Exercise + L/Zi: Rats with combined treatment of L/Zi (100 mg L/Zi/kg BW) and regular exercise. The exercise practice was carried out on a motor-driven rodent treadmill at 25 m/min, 45 min/day, 5 d/week for 8 wks.

Results: Rats with combined treatment of L/Zi (100 mg L/Zi/kg BW) and regular exercise. The exercise practice was carried out on a motor-driven rodent treadmill at 25 m/min, 45 min/day, 5 d/week for 8 wks. Brain nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and heme oxygenase-1(HO-1) levels increased and nuclear factor (NF-κB) reduced in the combined group. In addition, L/Zi supplementation increased cerebral cortex brain-derived neurotrophic factor (BDNF), synapsin I, synaptophysin (SYP) and growth-associated protein-43 (GAP-43) levels both control and exercised rats (<0.001 for all). The highest cerebral cortex BDNF, synapsin I, SYP and GAP-43 levels were detected in the combined group.

Conclusions: These results suggest that regular exercise training with L/Zi may improve brain function by regulating transcription and brain-derived neurotrophic factors and synaptic proteins in rats.

Funding Sources: This study was supported by the Omniactive Health Technologies (NJ, USA) and partially supported by the Turkish Academy of Sciences (Ankara, Turkey).

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