Red yeast increases excretion of bile acids in hamsters. - GreenMedInfo Summary
Red yeast rice increases excretion of bile acids in hamsters.
Biomed Environ Sci. 2009 Aug;22(4):269-77. PMID: 19950521
Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
OBJECTIVE: To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism. METHODS: Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR (0.1RYR) or 0.3% RYR (0.3RYR). Blood (0.5 mL) was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0, 3, and 6. Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography. RESULTS: Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by 11% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, liver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7alpha-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K. It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 3-4 folds compared with the control value. CONCLUSION: Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.