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Abstract Title:

Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis.

Abstract Source:

Arch Biochem Biophys. 2015 Aug 20 ;583:150-157. Epub 2015 Aug 20. PMID: 26297952

Abstract Author(s):

C Gardi, K Bauerova, B Stringa, V Kuncirova, L Slovak, S Ponist, F Drafi, L Bezakova, I Tedesco, A Acquaviva, S Bilotto, G L Russo

Article Affiliation:

C Gardi

Abstract:

Novel therapies for rheumatoid arthritis also include the use of naturally occurring compounds possessing antioxidant properties. In the present work, the effects of oral administration of quercetin were investigated in a rat model of adjuvant arthritis. Arthritis was induced by a single intradermal injection of heat-inactivated Mycobacterium butyricum in incomplete Freund's adjuvant. The experimental groups were treated with an oral daily dose of 150 mg/kg b.w. of quercetin for 28 days. Results indicated that quercetin was able to ameliorate all markers of inflammation and oxidative stress measured. Quercetin lowered levels of interleukin-1β, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity. Inaddition, quercetin inhibited the enzymatic activity of pro-inflammatory 12/15-lipoxygenase in lung and liver and increased the expression of heme oxygenase-1 in joint and lung of arthritic rats. Finally, quercetin inhibited the 2-fold increase of NF-қB activity observed in lung, liver and joint after induction of arthritis.

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Sayer Ji
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