Hepato-protective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats.
Can J Physiol Pharmacol. 2018 Feb 7. Epub 2018 Feb 7. PMID: 29414242
Nehal Aly Afifi
Despite all the studies performed up to now, therapy choices for liver injuries are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. The Quercetin (QR) and ellagic acid (EA) had a potent antioxidant and anti-inflammatory activities. The current study aimed at evaluating the potential hepatoprotective influence of QR and EA against thioacetamide (TAA)-induced liver toxicity in rats and the underlying mechanism using silymarin as a reference drug. Fifty mature male rats were orally daily treated with EA and QR in separate groups for 45 consecutive days, and then were injected with TAA twice with 24 hours interval in the last two days of the experiment. Administration of TAA resulted in marked elevation of liver indices, alteration in oxidative stress parameters and significant elevation in expression level of fibrosis related genes (MMP9 and MMP2). Administration of QR and EA significantly attenuated the hepatic toxicity through reduction of liver biomarkers, improving the redox status of the tissue as well as hampered the expression level of fibrosis related genes. In conclusion, QR and EA were proved to attenuate the hepatotoxicity through its antioxidant, metal chelating capacity and anti-inflammatory effects.