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Abstract Title:

[Effects of puerarin on renal function, expressions of MMP-2 and TIMP-2 in diabetic rats].

Abstract Source:

Yao Xue Xue Bao. 2004 Jul ;39(7):481-5. PMID: 15493832

Abstract Author(s):

Hui-Jun Duan, Shu-Xia Liu, Yu-Jun Zhang, Qing-Juan Liu, Ning He, Ying-Min Li

Article Affiliation:

Hui-Jun Duan

Abstract:

AIM: To investigate the effect of puerarin on expressions of MMP-2 and TIMP-2 in the kidney of diabetic rats.

METHODS: Uninephrectomized male Wistar rats were used to induce diabetes by intraperitoneal injection of streptozocin (65 mg x kg(-1)). Puerarin was given daily by intraperitoneal injection from the third day of induction of diabetes for 16 weeks. Using in situ hybridization and immunohistochemistry to detect MMP-2, TIMP-2 mRNA expressions and MMP-2, TIMP-2, collagen IV and Laminin expressions in diabetic kidneys with image analysis system, Flow cytometry was used to detect the expressions of TGFbeta1, MMP-2 and TIMP-2.

RESULTS: Compared with those in kidneys of control group, expressions of MMP-2 mRNA and proteins were lower, while the expressions of both TGFbeta1 and TIMP-2 were higher in the diabetic kidney (P<0.05). The level of MMP-2 expression was advanced, while expression of TIMP-2 was reduced by puerarin treatment (P<0.05).

CONCLUSION: Puerarin showed some renal protective effect on diabetic nephropathy, partly through inhibition of excessive deposition of glomeruli extracellular matrix by up-regulating MMP-2 and down-regulating TIMP-2 expressions besides reducing the blood glucose.

Study Type : Animal Study

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