Puerarin relieves paclitaxel-induced neuropathic pain. - GreenMedInfo Summary
Puerarin Relieves Paclitaxel-Induced Neuropathic Pain: The Role of Na1.8β1 Subunit of Sensory Neurons.
Front Pharmacol. 2018 ;9:1510. Epub 2019 Jan 7. PMID: 30666203
Currently there is no effective treatment available for clinical patients suffering from neuropathic pain induced by chemotherapy paclitaxel. Puerarin is a major isoflavonoid extracted from the Chinese medical herb kudzu root, which has been used for treatment of cardiovascular disorders and brain injury. Here, we found that puerarin dose-dependently alleviated paclitaxel-induced neuropathic pain. At the same time, puerarin preferentially reduced the excitability and blocked the voltage-gated sodium (Na) channels of dorsal root ganglion (DRG) neurons from paclitaxel-induced neuropathic pain rats. Furthermore, puerarin was a more potent blocker of tetrodotoxin-resistant (TTX-R) Nachannels than of tetrodotoxin-sensitive (TTX-S) Nachannels in chronic pain rats' DRG neurons. In addition, puerarin had a stronger blocking effect on Na1.8 channels in DRG neurons of neuropathic pain rats andβ1 subunit siRNA can abolish this selective blocking effect on Na1.8. Together, these results suggested that puerarin may preferentially blockβ1 subunit of Na1.8 in sensory neurons contributed to its anti-paclitaxel induced neuropathic pain effect.