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Abstract Title:

Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta.

Abstract Source:

Conf Proc IEEE Eng Med Biol Soc. 2004 ;5:3757-60. PMID: 17271112

Abstract Author(s):

K Dong, Q-M Tao, Q-X Shan, H-F Jin, G-B Pan, J-Z Chen, J-H Zhu, Q Xia

Article Affiliation:

K Dong

Abstract:

To investigate the vasorelaxant effect of puerarin, tension was recorded from rat thoracic aortic rings. Puerarin completely relaxed the contractions induced by phenylephrine (PE) in a concentration-dependent manner in endothelium-intact and endothelium-denuded rat aorta, while had no effect on those preconstricted by a high concentration of potassium chloride (60 mM). Also, puerarin had no effects on the transient contraction elicited by PE or caffeine in Ca2+- free medium. The relaxant effect of puerarin was significantly inhibited by pretreatment of endothelium-denuded aorta with potassium channel antagonists tetraethylammonium and 4-aminopyridine, but not glibenclamide. These results indicate that puerarin induces an endothelium-independent relaxation in rat aortic rings. The mechanisms may involve the reduction in Ca2+ influx through the non-voltage-sensitive calcium channels and the activation of the potassium channels (voltage-activated K+ channels and large conductance Ca2+ -activated K+ channels, but not ATP-sensitive K+ channels).

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Vasodilator Agents : CK(347) : AC(74)

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Sayer Ji
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