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Abstract Title:

Effects of Pu-erh ripened tea on hyperuricemic mice studied by serum metabolomics.

Abstract Source:

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15 ;1068-1069:149-156. Epub 2017 Oct 4. PMID: 29069630

Abstract Author(s):

Ran Zhao, Dong Chen, Hualing Wu

Article Affiliation:

Ran Zhao

Abstract:

To evaluate effects of Pu-erh ripened tea in hyperuricemic mice, a mouse hyperuricemia model was developed by oral administration of potassium oxonate for 7 d. Serum metabolomics, based on gas chromatography-mass spectrometry, was used to generate metabolic profiles from normal control, hyperuricemic and allopurinol-treated hyperuricemic mice, as well as hyperuricemic mice given Pu-erh ripened tea at three doses. Pu-erh ripened tea significantly lowered serum uric acid levels. Twelve potential biomarkers associated with hyperuricemia were identified. Pu-erh ripened tea and allopurinol differed in their metabolic effects in the hyperuricemic mice. Levels of glutamic acid, indolelactate, L-allothreonine, nicotinoylglycine, isoleucine, l-cysteine and glycocyamine, all involved in amino acid metabolism, were significantly changed in hyperuricemic mice treated Pu-erh ripened tea. Thus, modulating amino acid metabolism might be the primary mechanism of anti-hyperuricemia by Pu-erh ripened tea.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Uricosuric Agents : CK(2) : AC(1)

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Sayer Ji
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