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Abstract Title:

Protective effect of wild ginseng cambial meristematic cells on d-galactosamine-induced hepatotoxicity in rats.

Abstract Source:

J Ginseng Res. 2015 Oct ;39(4):376-83. Epub 2015 Apr 30. PMID: 26869831

Abstract Author(s):

Seok-Joo Kim, Hyo-Sun Choi, Hong-Ik Cho, Young-Woo Jin, Eun-Kyong Lee, Jeung Youb Ahn, Sun-Mee Lee

Article Affiliation:

Seok-Joo Kim

Abstract:

BACKGROUND: Panax ginseng has a wide range of biological activities including anti-inflammatory, antioxidant, and immunomodulatory functions. Wild ginseng cambial meristematic cells (CMCs) were obtained from P. ginseng cambium. This study examined the protective mechanism of wild ginseng CMCs against d-galactosamine (GalN)-induced liver injury. GalN, a well-known hepatotoxicant, causes severe hepatocellular inflammatory damage and clinical features similar to those of human viral hepatitis in experimental animals.

METHODS: Hepatotoxicity was induced in rats using GalN (700 mg/kg, i.p.). Wild ginseng CMCs was administered orally once a day for 2 wks, and then 2 h prior to and 6 h after GalN injection.

RESULTS: Wild ginseng CMCs attenuated the increase in serum aminotransferase activity that occurs 24 h after GalN injection. Wild ginseng CMCs also attenuated the GalN-induced increase in serum tumor necrosis factor-α, interleukin-6 level, and hepatic cyclooxygenase-2 protein and mRNA expression. Wild ginseng CMCs augmented the increase in serum interleukin -10 and hepatic heme oxygenase-1 protein and mRNA expression that was induced by GalN, inhibited the increase in the nuclear level of nuclear factor-kappaB, and enhanced the increase in NF-E2-related factor 2.

CONCLUSION: Our findings suggest that wild ginseng CMCs protects liver against GalN-induced inflammation by suppressing proinflammatory mediators and enhancing production of anti-inflammatory mediators.

Study Type : Animal Study

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Sayer Ji
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