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Abstract Title:

[Protective effect of puerarin on the secondary spinal cord injury in rats].

Abstract Source:

Zhong Yao Cai. 2009 Mar ;32(3):395-7. PMID: 19565720

Abstract Author(s):

Li-Song Heng, Bin-Shang Lan, Zhen Jia, Peng-Fei Wang, Li-Ying Fan

Article Affiliation:

Li-Song Heng

Abstract:

OBJECTIVE: To research the protective effect of puerarin on secondary spinal cord injury (SCI) in rats.

METHODS: After the models of SCI were established by improved Allen's method on adult male SD rats, SOD, MDA, Bcl-2 and Bax gene protein expression between puerarin group and model group were compared after 1, 6, 12, 24 and 48 h.

RESULTS: Puerarin could significantly enhance the activity of SOD and reduce the content of MDA, increase the expression of Bcl-2 gene protein products and decrease Bax gene protein product.

CONCLUSIONS: Puerarin can increase the activity of SOD, reduce the content of MDA, promote the expession of Bcl-2 and restrain the expression of Bax in the early spinal cord injury. It has protective effect on the secondary spinal cord injury.

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