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Abstract Title:

Concentration-Dependent Protection by Ethanol Extract of Propolis againstγ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes.

Abstract Source:

J Neurol Sci. 2001 May 1;186(1-2):81-5. PMID: 20981159

Abstract Author(s):

A Montoro, J F Barquinero, M Almonacid, A Montoro, N Sebastià, G Verdú, V Sahuquillo, J Serrano, M Saiz, J I Villaescusa, J M Soriano

Article Affiliation:

Servicio de Protección Radiológica, Hospital Universitario La Fe, 46009 Valencia, Spain.

Abstract:

Radioprotection with natural products may be relevant to the mitigation of ionizing radiation-induced damage in mammalian systems; in this sense, propolis extracts have shown effects such as antioxidant, antitumoral, anti-inflammatory, and immunostimulant. We report for the first time a cytogenetic study to evaluate the radioprotective effect, in vitro, of propolis against radiation-induced chromosomal damage. Lymphocytes were cultured with increasing concentrations of ethanol extract of propolis (EEP), including 20, 40, 120, 250, 500, 750, 1000, and 2000 μg mL(-1) and then exposed to 2 Gy γ-rays. A significant and concentration-dependent decrease is observed in the frequency of chromosome aberrations in samples treated with EEP. The protection against the formation of dicentrics was concentration-dependent, with a maximum protection at 120 μg mL(-1) of EEP. The observed frequency of dicentrics is described as negative exponential function, indicating that the maximum protectible fraction of dicentrics is approximately 44%. Free radical scavenging and antioxidant activities are the mechanisms that these substances use to protect cells from ionizing radiation.

Study Type : In Vitro Study

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Sayer Ji
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