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Abstract Title:

Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis.

Abstract Source:

Inflammopharmacology. 2018 May 11. Epub 2018 May 11. PMID: 29752572

Abstract Author(s):

Kahina Touri, Houda Belguendouz, Oussama Medjeber, Zineb Djeraba, Karima Lahmar, Chafia Touil-Boukoffa

Article Affiliation:

Kahina Touri

Abstract:

In this study, we evaluated the preventive and curative effects of ethanolic extract of Propolis (EEP) duringα-Tropomyosin-induced uveitis in an experimental model using Wistar rats, through the regulation of inducible nitric oxide synthase (NOS2) and arginase-1. In this context, rats received daily injection of EEP (100 mg/kg) for 5 days prior to immunization or for 9 days commencing 5 days post immunization with α-Tropomyosin extract, then were sacrificed at day 14. Histological examination, NOS2, arginase-1, and nuclear factor-κB (NF-κB) expression were evaluated in the retinas. Plasmatic production of nitric oxide (NO), urea, IL-4, and TNF-α was assessed. We have found that treatment with EEP substantially reduced the retinal histological damages induced by α-Tropomyosin. In the same context, a significant decrease of NO and TNF-α levels was noticed. Interestingly, EEP down-modulated NOS2 and NF-κB expression in retina. Also, an increase in urea and IL-4 levels was concomitantto an up-modulation of arginase-1 expression. Hence, it appears that EEP attenuated retinal damages through the induction of Th2 response and the inhibition of NF-κB/NOS2 pathway.

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