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Abstract Title:

Modulation of cisplatin cytotoxic activity against leiomyosarcoma cells by epigallocatechin-3-gallate.

Abstract Source:

Nat Prod Res. 2017 Jun 23:1-6. Epub 2017 Jun 23. PMID: 28641455

Abstract Author(s):

Irida Th Dhima, Dimitrios Peschos, Yannis V Simos, Maria I Gkiouli, Maria E Palatianou, Vasilios N Ragos, Vasiliki Kalfakakou, Angelos M Evangelou, Spyridon Ch Karkabounas

Article Affiliation:

Irida Th Dhima

Abstract:

The aim of this study was to investigate the cytotoxic effect cisplatin in combination with epigallocatechin-3-gallate (EGCG) on leiomyosarcoma cells (LMS cells) in order to identify a less toxic but equally effective alternative. Assays for cell proliferation, colony formation efficiency, induction of apoptosis and cell cycle arrest were performed using the IC50 of cisplatin (8.6 μΜ) as a reference value and a concentration of EGCG (30 μΜ) that caused a non-significant reduction in cell proliferation. Pre-treatment of cells with EGCG for 24 h before the addition of cisplatin increased cytotoxicity up to 8.5% (p < 0.05) and the number of apoptotic cells by 40%. Epigallocatechin-3-gallate failed to alter S-phase cell cycle arrest induced by cisplatin and to modulate cisplatin effects on mitochondrial function. These results indicate that pre-treatment with EGCG could be used as an adjunctive therapy to maximise effectiveness of chemotherapy.

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