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Article Publish Status: FREE
Abstract Title:

Pretreatment withβ-Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction: Role of eNOS Activation.

Abstract Source:

Sci Rep. 2015 ;5:15357. Epub 2015 Oct 20. PMID: 26482008

Abstract Author(s):

Mingming Wang, Minchun Chen, Yi Ding, Zhihui Zhu, Yikai Zhang, Peifeng Wei, Jingwen Wang, Yi Qiao, Liang Li, Yuwen Li, Aidong Wen

Article Affiliation:

Mingming Wang

Abstract:

Vascular endothelial cells play an important role in modulating anti-thrombus and maintaining the natural function of vascular by secreting many active substances.β-boswellic acid (β-BA) is an active triterpenoid compound from the extract of boswellia serrate. In this study, it is demonstrated that β-BA ameliorates plasma coagulation parameters, protects endothelium from blood stasis induced injury and prevents blood stasis induced impairment of endothelium-dependent vasodilatation. Moreover, it is found that β-BA significantly increases nitric oxide (NO) and cyclic guanosine 3', 5'-monophosphate (cGMP) levels in carotid aortas of blood stasis rats. To stimulate blood stasis-like conditions in vitro, human umbilical vein endothelial cells (HUVECs) were exposed to transient oxygen and glucose deprivation (OGD). Treatment of β-BA significantly increased intracellular NO level. Western blot and immunofluorescence as well as immunohistochemistry reveal that β-BA increases phosphorylation of enzyme nitric oxide synthase (eNOS) at Ser1177. In addition, β-BA mediated endothelium-dependent vasodilatation can be markedly blocked by eNOS inhibitor L-NAME in blood stasis rats. In OGD treated HUEVCs, the protective effect of β-BA is attenuated by knockdown of eNOS. In conclusion, the above findings provide convincing evidence for the protectiveeffects of β-BA on blood stasis induced endothelial dysfunction by eNOS signaling pathway.

Study Type : Animal Study

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Sayer Ji
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