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Article Publish Status: FREE
Abstract Title:

Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root.

Abstract Source:

Molecules. 2017 Aug 25 ;22(9). Epub 2017 Aug 25. PMID: 28841174

Abstract Author(s):

Liangliang Cai, Dongwei Wan, Fanglian Yi, Libiao Luan

Article Affiliation:

Liangliang Cai

Abstract:

In this study, purification, preliminary characterization and hepatoprotective effects of water-soluble polysaccharides from dandelion root (DRP) were investigated. Two polysaccharides, DRP1 and DRP2, were isolated from DRP. The two polysaccharides wereα-type polysaccharides and didn't contain protein. DRP1, with a molecular weight of 5695 Da, was composed of glucose, galactose and arabinose, whereas DRP2, with molecular weight of 8882 Da, was composed of rhamnose, galacturonic acid, glucose, galactose and arabinose. The backbone of DRP1 was mainly composed of (1→6)-linked-α-d-Glc and (1→3,4)-linked-α-d-Glc. DRP2 was mainly composed of (1→)-linked-α-d-Ara and (1→)-linked-α-d-Glc. A proof-of-concept study was performed to assess the therapeutic potential of DRP1 and DRP2 in a mouse model that mimics acetaminophen (APAP) -inducedliver injury (AILI) in humans. The present study shows DRP1 and DRP2 could protect the liver from APAP-induced hepatic injury by activating the Nrf2-Keap1 pathway. These conclusions demonstrate that the DRP1 and DRP2 might be suitable as functional foods and natural drugs in preventing APAP-inducedliver injury.

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