Polygonum cuspidatum and Polygonum multiflorum contain anti-HIV activity. - GreenMedInfo Summary
Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum.
Planta Med. 2010 Jan 28. Epub 2010 Jan 28. PMID: 20112182
Lab of Toxicology&Pharmacology, Faculty of Naval Medicine, The Second Military Medical University, Shanghai, P. R. China.
The 70 % EtOH extract of POLYGONUM CUSPIDATUM showed inhibitory action against HIV-1-induced syncytium formation at non-cytotoxic concentrations IN VITRO with a 50 % effective concentration (EC (50)) of 13.94 +/- 3.41 microg/mL. Through bioactivity-guided fractionation, 20 phenolic compounds, including eight stilbenoids, were isolated from the roots of POLYGONUM CUSPIDATUM, and their anti-HIV-1 activities were evaluated. Results showed that compounds 1, 13, 14, and 16 demonstrated fairly strong antiviral activity against HIV-1-induced cytopathic effects in C8166 lymphocytes at non-cytotoxic concentrations, with EC (50) values of 4.37 +/- 1.96 microg/mL, 19.97 +/- 5.09, 14.4 +/- 1.34 microg/mL, and 11.29 +/- 6.26 microg/mL and therapeutic index (TI) values of 8.12,>10.02,>13.89, and>17.71, respectively. Other compounds showed either weak or no effects. Compound 6 also showed weak inhibition (153.42 +/- 19.25 microg/mL); however, it possesses very good water solubility and showed almost no cytotoxicity (>2000 microg/mL), therefore achieving a fairly good TI (13.04). The activities of the two compounds ( 3 and 18) from POLYGONUM MULTIFLORUM were also assayed. The relationship between molecular structures and their bioactivities was also discussed.