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Abstract Title:

Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells.

Abstract Source:

Phytother Res. 2007 Sep ;21(9):898-9. PMID: 17582594

Abstract Author(s):

Ahmed Amir Radwan Sayed, Michael Morcos

Article Affiliation:

Ahmed Amir Radwan Sayed

Abstract:

The inhibitory effects of thymoquinone (TQ) on activation of the redox-sensitive transcription factor nuclear factor kappa B (NF-kappaB) and interleukin-6 (IL-6) were studied in vitro. Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE-induced NF-kappaB-activation and Il-6 expression was observed. This points to potential antioxidative qualities of TQ.

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