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Abstract Title:

Neuroprotective effects of alkaloids from Piper longum in a MPTP-induced mouse model of Parkinson's disease.

Abstract Source:

Pharm Biol. 2015 Oct ;53(10):1516-24. Epub 2015 Apr 10. PMID: 25857256

Abstract Author(s):

Ying Bi, Peng-Cheng Qu, Qing-Song Wang, Li Zheng, Hao-Long Liu, Rong Luo, Xiao-Qing Chen, Yin-Ying Ba, Xia Wu, Hui Yang

Article Affiliation:

Ying Bi

Abstract:

CONTEXT: Alkaloids of Piper longum L. (Piperaceae) (PLA) include piperine and piperlonguminine. Piper longum and piperine have multiple biological properties including antioxidant activity.

OBJECTIVE: The present study investigated the neuroprotective effects of PLA in a MPTP-induced mouse model of Parkinson's disease.

MATERIALS AND METHODS: PLA was prepared by extracting the dry seed of P. longum using 85% ethanol. Adult male C57BL/6 mice were divided into eight groups of 12 rats each. Experimental and control groups received an equivalent volume of saline, 0.5% CMC-Na, and 0.1% Tween 80, treated groups received oral PLA (30, 60, and 120 mg/kg), other groups treated with piperine (60 mg/kg) or Madopar (50 mg/kg). The PLA prevention group (PLA-Pr) administrated PLA (120 mg/kg) for 1 week before MPTP challenged. Except for the PLA-Pr group, others were treated for seven consecutive weeks. Parkinson's disease was induced by injecting MPTP intraperitoneally (25 mg/kg) twice weekly for five consecutive weeks. Dopaminerigic (DA) neurons and their metabolism were detected by UFLC-MS/MS. Tyrosine hydroxylase (TH)-immunohistochemistry assay and Western blotting were performed. The antioxidant enzymatic levels were determined by kit-based assays.

RESULTS: The LD50 value of PLA was determined at 1509 mg/kg of body weight. PLA (60 mg/kg) can significantly increase total movement time and distance (p<0.05), increase levels of DA (p<0.05) and DOPAC (p<  .05), increase glutathione (GSH) level and superoxide dismutase (SOD) activity (p<0.05), and decrease the lipid peroxidation of malondiadehycle (MDA) (p<0.05) in PLA-treated groups as compared with the control group.

DISCUSSION AND CONCLUSION: Our results indicate that PLA possesses neuroprotective effects and has ameliorative properties in dopaminergic neurons.

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