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Abstract Title:

Photoprotective and Antigenotoxic Effects of the Flavonoids Apigenin, Naringenin and Pinocembrin.

Abstract Source:

Photochem Photobiol. 2019 Jan 12. Epub 2019 Jan 12. PMID: 30636010

Abstract Author(s):

Adriana García Forero, Diego Armando Villamizar Mantilla, Luis A Núñez, Raquel Elvira Ocazionez, Elena E Stashenko, Jorge Luis Fuentes

Article Affiliation:

Adriana García Forero

Abstract:

This work evaluated the photoprotective and antigenotoxic effects against ultraviolet B (UVB) radiation of flavonoid compounds apigenin, naringenin and pinocembrin. The photoprotective efficacy of these compounds was estimated using in vitro photoprotection indices, and the antigenotoxicity against UVB radiation was evaluated using the SOS chromotest and an enzymatic (proteinase K/T4 endonuclease V enzyme) comet assay in UV-treated Escherichia coli and human (HEK-293) cells, respectively. Naringenin and pinocembrin showed maximum UV-absorption peak in UVC and UVB zones, while apigenin showed UV-absorption capability from UVC to UVA range. These compounds acted as UV filters reducing UV-induced genotoxicity, both in bacteria and in human cells. The enzymatic comet assay resulted highly sensitive for detection of UVB-induced DNA damage in HEK-293 cells. In this work, the photoprotective potential of these flavonoids was widely discussed.

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Sayer Ji
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