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Article Publish Status: FREE
Abstract Title:

Dihydrochalcone Compounds Isolated from Crabapple Leaves Showed Anticancer Effects on Human Cancer Cell Lines.

Abstract Source:

Molecules. 2015 ;20(12):21193-203. Epub 2015 Nov 27. PMID: 26633321

Abstract Author(s):

Xiaoxiao Qin, Yun Feng Xing, Zhiqin Zhou, Yuncong Yao

Article Affiliation:

Xiaoxiao Qin

Abstract:

Seven dihydrochalcone compounds were isolated from the leaves of Malus crabapples, cv."Radiant", and their chemical structures were elucidated by UV, IR, ESI-MS,¹H-NMR and (13)C-NMR analyses. These compounds, which include trilobatin (A1), phloretin (A2), 3-hydroxyphloretin (A3), phloretin rutinoside (A4), phlorizin (A5), 6''-O-coumaroyl-4'-O-glucopyranosylphloretin (A6), and 3'''-methoxy-6''-O-feruloy-4'-O-glucopyranosyl-phloretin (A7), all belong to thephloretin class and its derivatives. Compounds A6 and A7 are two new rare dihydrochalcone compounds. The results of a MTT cancer cell growth inhibition assay demonstrated that phloretin and these derivatives showed significant positive anticancer activities against several human cancer cell lines, including the A549 human lung cancer cell line, Bel 7402 liver cancer cell line, HepG2 human ileocecal cancer cell line, and HT-29 human colon cancer cell line. A7 had significant effects on all cancer cell lines, suggesting potential applications for phloretin and its derivatives. Adding a methoxylgroup to phloretin dramatically increases phloretin's anticancer activity.

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Sayer Ji
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