Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). - GreenMedInfo Summary
Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus).
Molecules. 2015 Jan 7 ;20(1):754-79. Epub 2015 Jan 7. PMID: 25574819
The female inflorescences of hops (Humulus lupulus L.), a well-known bittering agent used in the brewing industry, have long been used in traditional medicines. Xanthohumol (XN) is one of the bioactive substances contributing to its medical applications. Among foodstuffs XN is found primarily in beer and its natural occurrence is surveyed. In recent years, XN has received much attention for its biological effects. The present review describes the pharmacological aspects of XN and summarizes the most interesting findings obtained in the preclinical research related to this compound, including the pharmacological activity, the pharmacokinetics, and the safety of XN. Furthermore, the potential use of XN as a food additive considering its many positive biological effects is discussed.