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Abstract Title:

Biological activity of persimmon (Diospyros kaki) peel extracts.

Abstract Source:

Phytother Res. 2003 May;17(5):495-500. PMID: 12748986

Abstract Author(s):

Masami Kawase, Noboru Motohashi, Kazue Satoh, Hiroshi Sakagami, Hideki Nakashima, Satoru Tani, Yoshiaki Shirataki, Teruo Kurihara, Gabriella Spengler, Krisztina Wolfard, Joseph Molnár

Article Affiliation:

Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan. kawasema@josai.ac.jp

Abstract:

Fractionated extracts of persimmon (Diospyros kaki) peels were studied for cytotoxic activity, multidrug resistance (MDR) reversal activity, anti-human immunodeficiency virus (HIV) activity and anti-Helicobacter pylori (H. pylori) activity. The potent cytotoxic activity against human oral squamous cell carcinoma cells (HSC-2) and human submandibular gland tumor (HSG) cells was found in the acetone fractions (A4 and A5) with IC(50) ranging from 21 to 59 micro g/mL. However, the cytotoxic activity was not correlated with the radical intensity of the fractions. Three 70% MeOH extract fractions (70M2-4) produced radical and efficiently scavenged the O(2)(-) produced by hypoxanthine and xanthine oxidase reaction. All of the fractions tested were not effective for anti-H. pylori and anti-HIV. Fractions H3 and H4 of hexane extract, and M2 and M3 of MeOH extract showed a remarkable MDR reversal activity comparable with that of (+/-)-verapamil (a positive control). These results indicate the therapeutic value of persimmon peel extracts as potential antitumor and MDR-reversing agents.

Study Type : In Vitro Study

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Sayer Ji
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