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Abstract Title:

Increased cancer risk in patients with periodontitis.

Abstract Source:

Curr Med Res Opin. 2017 Jul 12:1-13. Epub 2017 Jul 12. PMID: 28699803

Abstract Author(s):

Omer Dizdar, Mutlu Hayran, Deniz Can Guven, Tolga Birtan Yılmaz, Sahand Taheri, Abdullah C Akman, Emre Bilgin, Beril Hüseyin, Ezel Berker

Article Affiliation:

Omer Dizdar

Abstract:

BACKGROUND: Previous studies have noted a possible association between periodontal diseases and the risk of various cancers. We assessed cancer risk in a cohort of patients with moderate to severe periodontitis.

METHODS: Patients diagnosed with moderate to severe periodontitis by a periodontist between 2001 and 2010 were identified from the hospital registry. Patients younger than 35 years of age or with a prior cancer diagnosis were excluded. The age- and gender-standardized incidence rates (SIR) was calculated by dividing the number of observed cases by the number of expected cases from Turkish National Cancer Registry 2013 data.

RESULTS: 280 patients were included (median age 49.6, 54% female). Median follow-up was 12 years. Twenty-five new cancer cases were observed. Patients with periodontitis had 77% the increased risk of cancer (SIR 1.77, 95% CI 1.17-2.58, p = 0.004). Women with periodontitis had significantly higher risk of breast cancer (SIR 2.40, 95% CI 0.88-5.33) and men with periodontitis had significantly higher risk of prostate cancer (SIR 3.75, 95% CI 0.95-10.21) and hematological cancers (SIR 6.97, 95% CI 1.77-18.98).

CONCLUSION: Although showing a casual association necessitates further investigation, our results support that periodontitis might be associated with increased cancer risk, particularly with hematological, breast and prostate cancers.

Study Type : Human Study

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