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Abstract Title:

Administration of perilla oil coated with Calshell increases glucagon-like peptide secretion.

Abstract Source:

Biol Pharm Bull. 2008 May;31(5):1021-3. PMID: 18451539

Abstract Author(s):

Tetsuya Adachi, Hiroyuki Yanaka, Hitoshi Kanai, Mayu Nozaki, Yoshiyuki Takahara, Mariko Tsuda, Tatsuya Jonouchi, Kinsuke Tsuda, Akira Hirasawa, Gozoh Tsujimoto

Article Affiliation:

Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. adachi-tet@umin.ac.jp

Abstract:

Recently, we found that unsaturated long-chain fatty acids (such as alpha-linolenic acid) promote the secretion of glucagon-like peptide-1 (GLP-1) via G protein-coupled receptor GPR120, which is expressed predominantly in the colon. In order to ensure that the triglycerides or free fatty acids, such as alpha-linolenic acid, reach the distal intestinal tract effectively, we developed a Calshell technique. Following single treatment of Calshell perilla oil powder, the GLP-1 secretion level was significantly higher than following vehicle treatment, 120 min after treatment. Next, we examined the effects of long-term Calshell perilla oil powder treatment on GLP-1 secretion. Plasma GLP-1 level of Calshell perilla oil powder treatment was significantly higher than of vehicle treatment for 1, 14, 28 and 56 d. We thereby demonstrated for the first time the utility of Calshell oil powder treatment for effective and sustainable GLP-1 secretion. The Calshell technique is apparently useful as a drug delivery system, since Calshell unsaturated oil powder is protected from gastric acid, reaches enteroendocrine cells in the gastrointestinal tract, and then induces effective incretin secretion.

Study Type : Animal Study

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