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Article Publish Status: FREE
Abstract Title:

Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway.

Abstract Source:

J Cardiovasc Transl Res. 2015 Dec ;8(9):536-44. Epub 2015 Nov 2. PMID: 26525047

Abstract Author(s):

Lulu Pan, Yuanhai Zhang, Jiacheng Lu, Zhimin Geng, Lianhong Jia, Xing Rong, Zhenquan Wang, Qifeng Zhao, Rongzhou Wu, Maoping Chu, Chunxiang Zhang

Article Affiliation:

Lulu Pan

Abstract:

This study is to determine the therapeutic effects of Panax notoginseng saponins (PNSs) on coxsackievirus B3 (CVB3)-induced myocarditis, and whether cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) pathway is involved. Mouse model of myocarditis was induced by CVB3 infection, and the mice were subjected to vehicle (saline) or drug treatments (sodium bisulfide (NaHS), propargylglycine (PAG), or PNSs). The results showed that there were inflammatory cell infiltrations, interstitial edemas, and elevated inflammatory cytokines, in CVB3-induced myocarditis. PAG administration increased, whereas NaHS treatment decreased the severity of the myocarditis. PNS treatment dramatically alleviated these myocardial injuries and decreased the viral messenger RNA (mRNA) expression by the enhanced expression of CSE/H2S pathway. Moreover, the therapeutic effects of PNSs on myocarditis were stronger than those of NaHS. Finally, the effect of PNSs on CSE/H2S pathway and cardiac cell protection were verified in cultured cardiac cells. PNSs may be a promising medication for viral myocarditis therapy.

Study Type : Animal Study

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