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Abstract Title:

[The Study of Protective Effect of Paeoniflorin on Lung Injury in MRL/lpr Mice].

Abstract Source:

Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 May ;49(3):394-398. PMID: 30014641

Abstract Author(s):

Chang-Hao Xie, Zhi-Jun Li, Lin-Jie Chen, Ping Zhao, Jia-Jia Zhang, Shan-Wang Bai, Tong Shen, Wen-Xin He, Yuan-Yuan Wang

Article Affiliation:

Chang-Hao Xie

Abstract:

OBJECTIVE: To investigate the protective effects of paeoniflorin on the lung injury in systemic lupus erythematosus with mouse model.

METHODS: Ten wild type mice and 40 MRL/lpr mice were used in this study. MRL/lpr mice were randomly assigned to MRL/lpr group,MRL/lpr + dexamethasone (1.5 mg/kg) group,MRL/lpr + paeoniflorin (20 mg/kg) group,and MRL/lpr + paeoniflorin (40 mg/kg). The levels of malondialdehyde (MDA) , superoxide dismutase (SOD) ,catalase (CAT) ,glutathione peroxidase (GSH-Px) in serum were detected. The serum levesl of inflammatory cytokines were measured. Lung pathological changes were determined by HE staining. The protein level of phospho-phosphatidylinositol-3 kinase (P-PI3K),phospho-serine-threonine kinase B(P-Akt) ,phospho-nuclear factor kappa B (P-NF-κB),phospho-inhibitor of nuclear factor kappa Bα (P-IκBα) were detected by Western blot.

RESULTS: Paeoniflorin decreased serum level of MDA and increased the levels of SOD,CAT,GSH-PX,and decreased the levels of inflammatory cytokines. Paeoniflorin improved lung pathological changes and inhibited the protein levels of P-PI3K,P-Akt,P-NF-κBp65,and P-IκBα in the lung tissue of MRL/lpr mice.

CONCLUSION: Paeoniflorin may be beneficial for the prevention of lung injury in systemic lupus erythematosus.

Study Type : Animal Study

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